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A brief overview of the history of vaccination in Oxford
The remarkable success of the Oxford AstraZeneca vaccine’s rapid development, testing and rollout presents a moment in time to look briefly back at the history of vaccination in Oxford. Since the pioneering works of Edward Jenner in the 18th century with smallpox vaccination and the social and economic issues that ensued, clear correlations can be seen to those same issues being encountered today with the COVID 19 pandemic.
Many of the issues encountered in the 18th century are currently familiar. They included inoculation resistance, misinformation and conspiracy theories, quarantine and isolation, reporting and surveillance, vaccine passports (a requirement to work) and incentivisation programmes.
Early inoculation
Edward Jenner is well known around the world for his innovative contribution to inoculation and the ultimate eradication of smallpox. Smallpox, the deadliest of all eighteenth-century diseases, was a terrible disease that spread from person to person without discrimination. It was widely feared, killing approximately 30% of those infected. After the initial symptoms of headache, muscle aches, exhaustion and fever, the body would become entirely covered in a rash, including inside the eyes, earning smallpox the epithet ‘Speckled Monster’. Jenner’s work is widely regarded as the foundation of immunology although its origins were in non-white cultures including China, Africa and later Turkey. Many people’s lives were saved from death and horrendous disfigurement thanks to Jenner’s remarkable work and the later developments from his endeavours.
His work started with Sarah Nelmes, a dairy maid, who had become infected with cowpox. On 14 May 1796, Jenner removed matter from pustules on her hand which he then used to inoculate an eight-year-old boy (James Phipps) who then also developed pustules but quickly recovered. On 1 July, Jenner performed the second stage of the experiment by inoculating James with smallpox. His aim was to see if the cowpox vaccine worked. This was long before medical ethics; the risk Jenner took with the boy’s life today seems unacceptable.
Vaccinating Oxford
In 1796 Finmere villagers were among the first to benefit from Edward Jenner’s smallpox vaccination and Robert Holt the local rector (among others) became an enthusiastic vaccinator. Holt’s achievements are noteworthy as he was untrained in medicine. His work is an early example of overcoming inoculation resistance as his parishioners trusted him and there was success in the majority of cases. Holt supplied other clergymen and small village doctors with vaccine and was a leader in dissemination. However, not the most sanitary of procedures were always employed and secondary infections could occur which led, in time, to villagers’ refusals. Holt recognised the experimental nature of the procedure and robustly documented his results; this work earned him considerable praise within the medical profession.